Thu. Jan 27th, 2022


    A transmission electron micrograph of SARS-CoV-2 virus particles (in gold) into the endosomes of a heavily infected nasal olfactory epithelial cell.

A transmission electron micrograph of SARS-CoV-2 virus particles (in gold) into the endosomes of a heavily infected nasal olfactory epithelial cell.
Pictures: NIH / NAID / IMAGE.FR / BSIP / Universal Images Group (Getty Images)

Researchers in Finland say They made A fancy nasal spray treatment that can provide short but effective protection against coronavirus and its various forms, Including Omicron. A recent preliminary study of rat cells, along with a Petri dish, found that nasal sprays prevent cells from becoming infected for the next eight hours. One dose, however, will be further studied This therapy should be done before expecting to reach people.

The experimental nasal spray is being developed by scientists at the University of Helsinki and relies on a slightly different approach to coronavirus treatment than other methods.

“Its prophylactic use to protect against SARS-CoV-2 infection,” S.tudy author Kalle Saksela Gizmodo says in an email. “However, it is not a vaccine, nor is it a substitute for a vaccine, but rather a complement to immunizations to provide extra protection for high-detail successful immunizations.”Risk situations, and especially for immunocompromised individuals উদাহরণ for example, who are receiving immunosuppressive therapy. “

Vaccines work by training the immune system to detect a bacterium without causing disease, which then allows us to create our own natural supply of antibodies and immune cells.If it appears in the future that germ ned. We have been able to extensively produce antibodies in the lab of coronavirus, known as monoclonal antibodies, which can be given to people after an exposure. Helsinki team treatment, of course A synthetic protein that is much smaller than an antibody, but one that can still recognize and bind to the spike protein of a virus. To further expand the potential of the protein, they combined the three into one package.

Theoretically, these antibody-like molecules can actively inhibit any coronavirus that comes in contact with successfully infected cells, at least for a short time. The ability to treat as a nasal spray means that these bodyguards can be sent directly to the respiratory tract, where most SARS-CoV-2 infections begin. Saxella, a virologist University of Helsinki, Be careful to note that Treatment is not intended To replace vaccines or other drugs.

Among them Research, published as a Preprint Late last month (i.e. it was not peer reviewed), How Saxella and colleagues describe Pseudovirus sprays have been tested to look like different forms of coronavirus, both of which have attempted to infect live cells as well as a Petri dish. Rats

Omicron has become one The main problem This is because many of its mutations prevent it from partially recognizing natural and lab-made antibodies. Made against the original strain of coronavirus. But Group molecules apparently target a region of the coronavirus spike protein that varies very little. Ideally, this means that even Omicron could not easily avoid obstacles.

At least in the lab, that’s what Saxella and her team found. Whether it’s Omicron, Delta, or the original SARS-CoV-2, The virus was off Once even a moderate dose of spray was given from infectious cells. And in rats exposed to beta variants of the virus, the presence of the virus in the upper respiratory tract and lungs of treated rats was significantly lower than in a control group, whose protection was evident up to eight. Hours Treatment after a single dose also seemed safe and was not associated with any noticeable harm.

Of course, this is all basic research that has not yet gone through the full peer-review process. So when The results are certainly encouraging, time will tell if their spray can work the same magic in humans. While their work should continue to show commitment, Saxella thinks Sprati will be valuable even after the end of the epidemic of Covid-19.

“This technology is cheap and highly productive, and works equally well against all forms of resistance,” he said. “It simply came to our notice then.The extinct SARS virus, therefore, could serve as an emergency measure against potential new coronaviruses (SARS-CoV-3 and -4). “

Saxella doesn’t know how long it will take Spray to reach the clinical trial, and from there to reach the market. He notes Depending on the regulatory process in a country, spray can be considered as a drug or medical device, which will further affect any timeline of development. But in addition to continuing work on the Covid-19 treatment, the team may later try to develop similar sprays for other respiratory infections.



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