New research Suggests that ketamine can help people fight alcohol addiction. Small randomized, controlled trials have shown that people with severe alcohol use reported abstinence from follow-up for six months longer than those in a control group when given ketamine infusion. The benefits seem to be even greater for people who are given ketamine in addition to psychotherapy.
Ketamine has long been used and sometimes used as a sedative for both humans and animals Taken As a recreational drug with hallucinogenic effects. In In recent years, it has taken on a different identity Treatment of depression. Since 2019, the Food and Drug Administration has approved a modified version of ketamine, available as a nasal spray for severe depression, combined with a combination of oral antidepressants, treatment-resistant depression and the concept of acute suicide.
Some scientists are hopeful that ketamine may also help people with alcoholism, based on some Preliminary research. But this new research, Published On Tuesday in the American Journal of Psychiatry, this is the first clinical trial of its kind.
These researchers The University of Exeter in the United Kingdom has recruited 96 people with a serious alcohol use disorder. The volunteers were divided into four groups, including T.wo group rTaking psychotherapy and attending two alcohol education sessions. Of these pairs, one would receive three ketamine infusions weekly and the other a placebo saline solution. Three months and six months after the first infusion, volunteers will self-report their alcohol withdrawal days and if they recur, which is defined as one or more days of heavy drinking.
There was no significant difference in the relapse rate between the ketamine and placebo groups. But those who received ketamine in both cases reported a higher percentage of days of abstinence from alcohol in both three and six months. The largest gap was observed between the group receiving ketamine and therapy and the placebo group receiving a placebo and no therapy with pre-reporting restraint for 162 days out of 180 days. Those who have taken Ketamine showed fewer symptoms of depression at three months and improved liver function compared to the placebo group. No serious adverse events were reported, although two volunteers withdrew ketamine from the trial because they could not tolerate the drug.
“Alcohol can ruin lives, and we urgently need new ways to help people lose weight. We’ve found that the combined use of psychotherapy with controlled, low-dose ketamine can help people stay away from alcohol for longer than placebo,” said lead author Celia. Morgan says Statement “It’s very encouraging, because we usually see three out of every four people returning to heavy drinking within six months of quitting alcohol, so this result represents a great improvement,” from the university.
The results are based on the size of a small sample, And research is only intended to be a proof of concept. So it will take more proof to know may be effective for ketamine Alcohol use disorder. Morgan and his team also believe that ketamine alone may not be an effective treatment for these individuals. IIn fact, it should be combined with therapy or counseling support and should only be used as a brief-Term help. But given the lack of other reliable effective alternatives, and Growing growth With excessive or harmful alcohol use (possibly partly due to the epidemic), researchers hope that ketamine may show promise and eventually become part of the treatment toolbox.
“This is a second-stage clinical trial, which means it is primarily conducted in humans to test the safety and feasibility of the treatment. We have now received an early indication that this treatment is effective. We now need a larger test to see if we can confirm these effects.” Morgan says.