The challenge of the Covid-19 vaccine for immunoprecipitation

Also, the body’s defenses are not the only defense to build immunity: we build too T cells, Memory B cells and others Clinical trials of vaccines have not attempted to measure the cells needed to create effective immunity against the virus attempt they only report Clinical Endpoints, such as whether someone became seriously ill or died of the disease as so focusing on antibodies alone can miss important parts of the immune response.

“When someone doesn’t make antibodies, I try not to use words like ‘you didn’t react’ to the vaccine,” “said Haider, the lead investigator. Larger studies Many people with immunodeficiency, including HIV, are being recruited to study the response to the covid vaccine. “I fear that the vaccine is not working for you if it is massaging, it could lead to vaccine hesitation. I think we need to be somewhat more neglected because of the complexity that other components of the immune system could recover through vaccines. “

Even in a few studies so far, it is clear that vaccines vary in immunity, depending on the age of the patient, the way they suffer from immunodeficiency, the type of transplant they receive, the specific medications they receive, the replacement or last dose, and a host of other factors. Length. Lots of antibodies are more likely to be produced, for example, in patients who take anti-inflammatory drugs than those who are transplanted and treated with cancer to treat chronic inflammatory diseases. Studies by Sezev and Tim later show better rates of antibody production in patients One And Two Dosage. A separate print, however, made by the Washington University School of Medicine in St. Louis and UC San Francisco, The show The response varies depending on which medication the patient is taking.

It can provide a formula for managing patients ’vulnerabilities, so that they can get closer to the kind of preventive protection that healthy people get from covid vaccines. Alfred H. J. Kim, a senior author on the staff and an assistant professor of rheumatology and immunology at the University of Washington, said: “Of course, if you hold on to drugs, you run the risk of flame. And if you stick to flame, it could make the side effects of your vaccine worse, or it could make the vaccine itself less effective.

And, legally, doctors cannot currently prescribe extra doses of the covid vaccine to patients. The FDA has approved only one or two doses for all vaccines that have entered the U.S. market. For the study of Sezev’s team, the physicians did not prescribe a third dose – the patients themselves received a third dose, the way the study did not specify. The Hopkins team tracked the results.

Nevertheless, there is some evidence in the medical literature to support the utility of additional doses. For example, the French government Recommended The third dose for those who are immunocompromised. And in the United States, it has been understood for years that one The second dose season you flu vaccine and Large doses Hepatitis B vaccines are needed to build immunity between them.

However, more data needs to be collected to ensure this. The Hopkins team is considering a larger test that will list third-dose immunosuppressed patients and track them in a formal way. And despite the high security persuasion, they are not urging resistant malignant patients to start freelancing on their own third shot. “There is a risk of taking a third dose,” Segev said. “There is a risk that the third dose will activate your immune system and cause either unexpected rejection or some kind of subclinical thing, where you start to make some more antibodies against your replaced organ. People who go out and take the third dose are either doing so as part of a research protocol or in collaboration with their physicians to assess their risks and benefits. “

If data can be obtained through such testsAnotherAs recently announced, the National Institutes of Health are operating – they can do more than just let immunocompressions get back into everyday life. They can also shed light on aspects of the immune system and its interactions with vaccines that are still not very well understood. And it will be beneficial not only during this epidemic, but also for what we need to protect ourselves against the next thing.

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